Diabetes is a disease that is related to microvascular and macrovascular diseases that affect several organs, which include skin, heart, muscles, brain, and kidneys. Diabetic microvascular complications involves small vessels like the capillaries and has similar etiological characteristics to those of macrovascular ones. Chronic hyperglycemia is a major initiator of diabetic vascular complications through various structural and metabolic derangements such as abnormal activation of signaling cascades.
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